Document 0115
 DOCN  M9490115
 TI    Duration of illness and neuropsychological performance in asymptomatic
       HIV infection.
 DT    9411
 AU    Bornstein RA; Nasrallah HA; Para MF; Whitacre CC; Fass RJ; Department of
       Psychiatry, Ohio State University College of; Medicine, Columbus.
 SO    J Neuropsychiatry Clin Neurosci. 1994 Spring;6(2):160-4. Unique
       Identifier : AIDSLINE MED/94319177
 AB    The relationship between duration of illness and neuropsychological
       performance was examined in 25 asymptomatic HIV-infected men with an
       estimated date of seroconversion. Mean duration of illness was
       approximately 2 years. After controlling for CD4 level at the time of
       neuropsychological examination, duration of illness was correlated with
       measures of visual attention, mental flexibility, dexterity, auditory
       information processing, and response fluency, as well as an overall
       measure of neuropsychological performance. Although these patients
       performed within normal limits, these data suggest that duration of
       infection may be related to subtle alterations in neuropsychological
       performance. These results are discussed with regard to possible
       mechanisms that implicate gradual accumulation of neurotoxins.
 DE    Adult  AIDS Dementia Complex/*DIAGNOSIS/IMMUNOLOGY/PSYCHOLOGY
       Bisexuality/PSYCHOLOGY  CD4-CD8 Ratio  Follow-Up Studies
       Homosexuality/PSYCHOLOGY  Human  HIV
       Infections/*DIAGNOSIS/IMMUNOLOGY/PSYCHOLOGY  HIV
       Seropositivity/*DIAGNOSIS/IMMUNOLOGY/PSYCHOLOGY  Longitudinal Studies
       Male  Middle Age  *Neuropsychological Tests  Support, U.S. Gov't, P.H.S.
       Time Factors  JOURNAL ARTICLE

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